The Extracellular Matrix: How fungi communicate and highjack the human body

The Extracellular Matrix: How fungi communicate and highjack the human body

Studies have shown that Fungi (Latin) or Molds (English) are microorganisms that can infect and take over the biological systems of humans.

They are so small, we cannot see them. But if we could, we would find that we live in a type of micoorganistic web that envelops all life and the entire globe within its filements.

Peer reviews studies over the last couple decades have found that they have the unique ability to possess, infiltrate, and control other organisms including plants, insects, animals and humans.

Many people today do not realize how these unseen forces like fungi play a large role in molding and human biology as it relates to microbial ecology, host-pathogen interactions, and cellular communication networks.

As we continue to unveil the mysteries of this intricate interplay, we open up new avenues for research and innovation that revolutionize our perception of the microbial world and its myriad of interactions.

One of the main methods or communication networks that fungi use to handle these tasks is via extracellular vesicles or EVs.

Fungi (Molds) don’t just release spores and toxins into the air. They send out tiny biological packages called extracellular vesicles (EVs) — nanoscale lipid-wrapped particles loaded with genetic material, proteins, enzymes, and virulence factors.

These aren’t accidental byproducts.

They are targeted delivery systems.

And they are designed to infiltrate your immune system, rewire your biology, and help fungal pathogens survive inside your body according to peer-reviewed studies from the NIH, PubMed, and major research institutions worldwide confirming that fungal EVs are active agents of human illness.

Think of a fungal extracellular vesicle as a biological delivery envelope.

It is a sphere wrapped in a lipid bilayer — the same type of membrane that surrounds every human cell — and it is packed with cargo the fungus deliberately loads inside it.

As a 2026 review published in World Journal of Microbiology and Biotechnology described them, fungal EVs are “sophisticated emissaries in cross-kingdom communication,” not mere cellular debris — they are “actively exported across the fungal cell wall via complex biogenesis mechanisms”.

That cargo includes nucleic acids (DNA and RNA), enzymes, lipids, polysaccharides, and virulence-related proteins. The fungus releases these vesicles across its cell wall and into the surrounding environment, including directly into human tissue during active infection.

The first EVs were observed in Aspergillus nidulans in 1972 and in Cryptococcus neoformans in 1973, but serious investigation into their role in human infection only intensified in the 2000s.

Today, fungal EVs have been identified in species including Candida albicans, Cryptococcus neoformans, Aspergillus fumigatus, Histoplasma capsulatum, Paracoccidioides brasiliensis, Malassezia sympodialis, and Sporothrix brasiliensis — covering a wide range of organisms that affect everyday people in their homes and workplaces.

How Fungi/Molds Infiltrate the Human Body

Interactions between cells via extracellular vesicles (EVs) represent a fascinating yet often overlooked aspect of human cellular and fungi communication.

Understanding how fungi release and uptake extracellular vesicles is essential for unraveling the intricate dance of communication between fungi and their environment. They have evolved over millions of years sophisticated mechanisms to manipulate host cells and evade immune responses.

These microscopic couriers transport their cargo across biological barriers allowing extracellular vesicles to influence cellular functions, modulate immune responses, and participate in the regulation of physiological processes.

When fungi grow within our bodies, they release EVs that create an extracellular filamentous matrix of biofilm around their hosts (victims), which acts as a protective layer against other microorganisms and antifungal drugs (Taff et al., 2012; Zarnowski et al., 2021).

For example, the fungus, Candida albicans, which resides in the human microbiome can regulate fungal virulence and biofilm formation via EVs (Honorato et al., 2022; Kulig et al., 2022).

The uptake of extracellular vesicles by fungi is a dynamic process that involves interactions between the vesicles and the fungal cell surface. Fungi have specific receptors and mechanisms for recognizing and internalizing extracellular vesicles.

Once internalized, the cargo carried by the vesicles can be released into the fungal cell, where it can modulate various cellular processes.

In biology, cell signaling is the process by which a cell interacts with itself, other cells, and the environment. This environment is in actuality an intricate web of filaments and cellular conversations that occur unseen within and around us.

Typically, the signaling process involves three components: The signal, the receptor, and the effector.

By interacting with EVs, fungi can hijack cellular communication pathways, deliver virulence factors, and promote their survival and proliferation within the host.

This interaction is particularly significant in the context of fungal pathogenesis, as it can influence the outcome of infections and the severity of disease manifestations.

Over recent years, the incidence of invasive fungal infections has surged, shedding light on the intricate role of fungal extracellular vesicles (EVs) in mediating intercellular communication and host-pathogen interactions. Moreover, recent research has shed light on the role of fungi EVs in the pathogenesis of diseases, including cancer, neurodegenerative disorders, and infectious diseases.

Thus influencing the dynamics of fungal-host cell interplay that can facilitate wound healing and when conditions are ripe, induce tissue damage, inflammatory responses, and various diseases.

How They Cross Into the Human Body

Here is the part that should concern every homeowner dealing with a mold problem: fungal EVs are small enough to penetrate biological barriers that would stop most fungal particles.

These vesicles range from as small as 30 nanometers to over 1 micron in size — well within the size range that penetrates the respiratory tract, crosses mucosal membranes, and enters the bloodstream.

During active infection, they have been detected directly in human blood and urine, confirming that they are circulating through the body of infected patients.

A 2024 study published by de Rezende and colleagues — later indexed through the NIH — examined EVs from the serum and urine of patients with confirmed infections from Candida albicans, Cryptococcus neoformans, and Paracoccidioides brasiliensis.

The researchers found that EVs from infected patients carried distinct lipid profiles — including sphingosine and phytosphingosine — not found in healthy control subjects, confirming the EVs were being produced during active human infection and circulating through biological fluids.

Fungal infections enter through two main routes: extrinsic (environmental fungi inhaled or absorbed from the outside) and intrinsic (fungi already present in the gut microbiome that become opportunistic under the right conditions).

Once inside a host, the fungi begin releasing EVs as part of their strategy to establish and maintain infection.

Genetic Material That Alters Human Gene Expression

Perhaps the most alarming aspect of fungal EVs is their ability to deliver RNA into human cells — and change how those cells behave.

Fungal EVs carry messenger RNA (mRNA), long non-coding RNAs (lncRNAs), small interfering RNAs (siRNAs), and other nucleic acid classes. Research on Candida albicans infection identified 10 up-regulated long non-coding RNAs in host cells that were specifically associated with infection, particularly related to “the response to injury”.

This suggests that fungal EVs may be actively reprogramming human gene expression to create a more favorable environment for fungal survival.

This is not a passive interaction.

The fungi appear to be using their EVs to send molecular instructions into human cells — instructions that alter immune responses, inflammatory signaling, and cellular behavior.

Comandering and taking over the very bodily systems that make us human

Immune Evasion: The Double-Edged Manipulation

The immune system’s response to fungal EVs is complicated — and that complexity is exactly what fungi exploit.

As a 2023 review in Frontiers in Microbiology described it, fungal EVs play a “double-edged sword” role: they can both stimulate and suppress the immune response, depending on the species, the concentration, and the specific cargo.

Fungi appear to have developed the ability to modulate which direction the immune response goes — triggering just enough inflammation to avoid being ignored, while simultaneously suppressing the responses that would eliminate them.

Cryptococcus neoformans EVs demonstrate this perfectly. On one hand, they trigger macrophages to produce tumor necrosis factor-alpha (TNF-α) and nitric oxide — pro-inflammatory signals. On the other hand, the same EVs carry GXM and stimulate the production of anti-inflammatory cytokines like TGF-β and IL-10, which suppress the immune system’s killing capacity.

The fungus essentially steps on the gas and the brakes at the same time, creating a state of immune confusion.

Candida albicans takes this even further.

Its EVs have been shown to activate complement receptor 3 (CR3) on monocytes, causing those monocytes to produce TGF-1-transporting vesicles of their own — human vesicles that then “suppress the immune response in blood vessels” and “attenuate systemic infection”.

The fungus hijacks the body’s own EV system to do its bidding.

ATP: The Unseen Fuel Fungi Exploit

One of the main extracellular signaling chemicals within the human body for fungi that also plays both a central role as an intracellular energy source is Adenosine 5′-triphosphate (ATP).

ATP is the primary energy currency of all living cells, from fungi and bacteria to plants and animals; if biological importance were ranked, it sits at the top of the pyramid.

ATP is the unseen fuel that makes the world go round, or more properly, oscillate clockwise, which is essential for various cellular processes, including brain function, muscle contraction, biosynthesis, and active transport processes in cells.

ATP synthesis is the process by which ATP is produced, typically occurring in the mitochondria of eukaryotic cells through cellular respiration by our microbiome. During this process, energy is generated and stored in the form of ATP, ready to be used for various cellular functions.

Active transport moves molecules or ions against their concentration gradient — a process requiring ATP hydrolysis — occurring either into cells (endocytosis) or out of them (exocytosis).

A prime example is the absorption of phosphorus by plant roots or our own microbiome. By contrast, passive transport moves ions from higher to lower concentration without energy expenditure, as in gas exchange in the lungs.

A bodily process that would require this active transport of energy to operate would be our brains in the act of thinking and problem solving.

On the contrary, passive transport moves ions from a higher concentration to lower concentration without any ATP energy like in the exchange of gases in the lungs and the exchange of nutrients in the kidneys.

ATP is created when we eat food, especially meat and dairy products.

When food is consumed, it undergoes digestion by our microbiome — i.e., fungi and bacteria — which we feed to break down our food into vitamins and ATP energy.

Without this community of microbes that lives symbiotically within and around us, we would not be able to break down the food we eat. Hence, we would simply not exist.

This is why they can become parasitic when we do not give these microbes the nutrients they require — as if there is an autonomous kill switch within our cells that turns on when we transgress against these natural laws.

Instead of eating the good food we supply them with, they will eat us, and the science proves this.

My contention is that this relationship can be compared to a master and slave dynamic, in that we are the slaves and they are our masters.

Gnostic Warrior Conclusion

Fungal extracellular vesicles are not a theoretical concern — they are an active biological reality unfolding inside homes, lungs, and bloodstreams right now.

These organisms are not passive invaders mindlessly releasing random toxins.

They are executing coordinated operations at the nanoscale, deploying molecular payloads with a precision that challenges everything mainstream medicine assumes about fungal pathogenicity.

We are not dealing with a simple mold problem.

We are witnessing a hidden war being waged at a global scale the naked eye cannot see and that conventional medicine has barely begun to acknowledge.

The ancient Gnostics understood that the most dangerous forces are the ones operating in concealment — and nowhere is that principle more relevant than here.

In Gnostic cosmology, archons (Greek: árchōn, meaning “ruler”) are described as malevolent cosmic rulers who govern the material world and keep souls imprisoned within it.

The Gnostic text Reality of the Rulers (Hypostasis of the Archons) describes them as having “bodies that are both female and male, and faces that are the faces of beasts” — boundary-crossing entities of chaos.

Their primary function is enforcing ignorance, feeding off human passions, and preventing spiritual ascension.

The microbes within us — bacteria, fungi, parasites — behave with a kind of ruthless autonomy that mirrors the archon’s role as internal ruler.

When well-fed and balanced, they are symbiotic partners. But when deprived of proper nutrition, gut parasites can literally re-engineer the internal ecosystem, alter tight junctions, invade epithelial cells, and cause dysbiosis — essentially turning against the host.

They are, in a very real biological sense, both female and male, and faces that are the faces of beasts with teeth that appear to be our defacto rulers.

Gnosticism teaches that humans carry a divine spark trapped within material constraints, and that liberation comes through self-knowledge rather than submission.

The knowledge exists.

The question is whether you will act on it.

References

Until you Make the Unconscious, Conscious: The Science of Bottom Up Thinking

Until you Make the Unconscious, Conscious: The Science of Bottom Up Thinking

Until you make the unconscious, conscious, it will direct your life and you will call it fate.” — Carl Gustav Jung, Psychology and Alchemy (1944)

Most people never notice the invisible hand at work — quietly pulling them back into the same bad behaviors, the same broken relationships, and the same traps they swore they’d never fall into again.

It operates below awareness, buried in old wounds and unexamined beliefs, running the show while the conscious mind convinces itself it’s finally in control.

The cycle doesn’t break itself. Most never even know there’s a cycle to break.

Some people call it fate. Some call it luck and others call it destiny.

Carl Jung called it something far more confronting: the unconscious mind operating without supervision.

This single sentence by Jung lays bare one of the most unsettling truths of modern psychology—that the grand architect of your life may not be you at all, but the hidden hand of your own psyche of secretly pulling the strings of your very being.

The people who do understand and get to know this unconscious part of themselves, are often victims of their own device.

A type of human puppet or automaton without a soul on a suicide mission.

As the ancient Delphic oracle commanded: “Know thyself,” and the The Hermetic axiom “As above, so below” we finds a striking parallel to Jungian philosophy and cognitive science: the mind’s architecture mirrors the universe’s hierarchy.

The lower (sensory, reactive) must be integrated with the higher (rational, transcendent) to produce genuine wisdom.

In the language of cognitive science, thinking styles exist on a spectrum between the lower and higher mind.

We also know today that we have a brain in our heads that has two separate sections or hemispheres with the left and right having specific functions and connections within the human body.

Research shows us that our brains in our skulls are permanently connected to our gastrointenstinal tracts in the stomach via the gut-brain axis.

Johns Hopkins Medicine describes the ENS as so sophisticated that it can operate largely independently of the brain, leading researchers to informally call it “the second brain.”

Studies have proven that the human body houses two interconnected nervous systems engaged in constant, bidirectional dialogue—a discovery that forces a fundamental reconsideration of how consciousness and perception actually work.

For example, Research into what scientists now call the gut-brain axis reveals that the human body houses two interconnected nervous systems engaged in constant, bidirectional dialogue—a discovery that forces a fundamental reconsideration of how consciousness and perception actually work.

Neuroscientists now describe cognition as a synthesis of bottom-up processing—raw sensory data streaming in from the environment—and top-down processing—the brain’s learned expectations, memories, and emotional states shaping how that data is interpreted.

In the language of cognitive science, thinking styles exist on a spectrum between two poles.

What is now becoming clear is that the gut, i.e. “the second brain” not only participates actively in this loop, but it can control it 100%.

Meaning, in some people today, especially with mental illness, this loop has been broken.

A broken loop that I contend can make someone lose their ability to be able to process information from the top down.

A person have lost the ability to truly think rationally, logically and act responsibly with the brain in their skulls.

Instead, they are secretly controlled by the organisms in their second brain who are controlling the nervous system like the strings on a puppet.

An all to often common event that can cause humans to become programmable automans based on the input of information over the course of their lives.

In order to understand human cognition, you need to that these two brains have different functions and abilities as it relates to thinking.

Much of our days are spent reacting without thinking because we are hardwired to operate without having to consciously think.

The two hemispheres in our brain along with our gut (second brain), the right and left have different functions in processing this information.

The right hemisphere is associated with automatic bottom-up processing and awareness of information holistically and relationally.

The left hemisphere is associated with top-down processing and focused attention to analyze and conceptualize information for language processing, logical thought, and simplifies information for easier processing.

Top-down thinking begins with a conceptual schema — a pre-existing framework, assumption, or narrative — and uses incoming data to confirm or adjust it.

A top-down thinker enters a room and immediately categorizes it: meeting room, formal, hierarchical. Their perception is shaped and filtered by inherited expectation.

Bottom-up thinking works in the opposite direction entirely.

The bottom-up thinker enters the same room and first registers its individual components: the hum of a fluorescent light, the power dynamics implicit in the seating arrangement, the emotional temperature of the people present.

Only after processing these granular inputs does a larger picture assemble.

As Simply Psychology researchers have documented, bottom-up processors “may focus more on specific parts of information rather than integrating it holistically” — a tendency that grants remarkable precision in detail but creates vulnerability to incomplete synthesis under pressure.

Obviously, we are still making decisions and reacting but this is done on the subconscious level as we move back and forth between conscious and unconscious forms of thought.

For example, how many of us speak and engage with one another is often done with little thought.

Scientists call this bottom up thinking.

Understanding bottom-up thinking — the cognitive architecture of those who act before they think — is not merely an academic exercise.

It is a map to one of the most misunderstood forms of human intelligence ever documented.

Bottom-up thinking is also known as condensed inner speech, which is the final stage of how we internalize our thoughts as we learn language and to talk to ourselves inside our heads. This concept was studied by psychologists like Vygotsky in 1934, Galperin in 1957, and Sokolov in 1967.

At this point, it happens naturally and without us even realizing it.

Meaning, some of our thoughts have now become automattic allowing habit formation.

Instead of using full sentences, we often just think in single words or phrases that match what we’re experiencing at the moment.

This type of speech happens in our minds that connects closely with our thinking, but it is automatic and autonomous.

It’s like how we automatically recognize sights and sounds, without really thinking about it—our brain processes it all in the background.

This would be what science calls a bottom–up perception of sensory input, most of which is processed automatically through implicit/unconscious neural mechanisms.

This bottom-up processing contributes to the development and execution of our habits, which are automatic behaviors, AKA repetitive actions that have become ingrained into our being and can be triggered by environmental cues without conscious thought.

In social interactions, this allows for rapid processing of facial expressions and body language guides our responses in social situations.

For people who engage in activities like sports or playing musical instruments, bottom-up processing allows for quick, fluid movements based on sensory feedback.

This process begins with the raw sensory data received by our sensory receptors and moves “up” to higher-level cognitive processing.

This allows humans to have quick reactions to environmental stimuli, which is crucial for survival and everyday functioning.

Rather than beginning with a broad conceptual framework and inserting details to confirm it, the bottom-up thinker starts with raw pieces of reality and gradually assembles them into a coherent whole.

In the language of formal logic, this is an inductive approach: evidence leads to theory, not the reverse.

It helps filter relevant sensory data, allowing us to focus on important cues.

The contrast with top-down thinking is stark and consequential.

Top-down thinking begins with the big picture — a pre-existing mental schema, an established expectation, a narrative inherited from culture or authority.

A top-down thinker looks at a room and immediately “reads” its social purpose.

A bottom-up thinker first registers the ticking clock, the quality of light, the texture of a surface, the emotional undercurrent in a voice — and only later assembles these raw percepts into something meaningful.

As researchers at Simply Psychology summarize it: bottom-up processors “may focus more on specific parts of information rather than integrating it holistically”.

In the simplest terms available: bottom-up thinking is data first, categorize later.

Act now, think later.

The modern rehabilitation of gut intelligence is largely credited to Dr. Michael D. Gershon of Columbia University, whose landmark 1998 book The Second Brain reignited scientific interest in the enteric nervous system (ENS).

Gershon described the bowel as “the only organ that contains an intrinsic nervous system able to mediate reflexes in complete absence of input from the brain or spinal cord,” and noted that the gut represented “a vast chemical warehouse featuring every class of neurotransmitter found in the brain”.

The human ENS contains between 200 and 600 million neurons—a complexity rivaling that of the spinal cord itself. It was the gut’s capacity to operate entirely independently of the cranial brain that led Gershon to call it the “second brain.”

Yet as Gershon himself noted, independence does not mean isolation: “While it’s no help in matters of philosophy, poetry, and other forms of deep thought, this second brain and how it interacts with the first one is a key factor in our physical and mental well-being”.

The Vagus Nerve: The Body and Minds Secret Highway

The primary communication channel between these two brains is the vagus nerve—cranial nerve X—one of the longest and most complex nerves in the human body.

A 2018 review published in Frontiers in Psychiatry described the vagus nerve as “the main component of the parasympathetic nervous system, which oversees a vast array of crucial bodily functions, including control of mood, immune response, digestion, and heart rate”.

Crucially, the vagus nerve sends information in both directions, but approximately 80–90 percent of its fibers carry signals upward, from gut to brain—not downward.

The body, in other words, is informing the mind far more often than the mind is directing the body.

The microbiome housed in the digestive tract produces neurotransmitters including serotonin, dopamine, and GABA—the very same chemical messengers that regulate thought, emotion, and awareness.

An estimated 90–95 percent of the body’s serotonin, widely associated with feelings of well-being and mental stability, is produced not in the brain but in the gut by microorganisms.

In 2018, researcher Maya Kaelberer and her team at Duke University made a landmark discovery: the gut communicates with the brain not only through slow hormonal signaling but through fast, direct neural connections.

They identified specialized sensory cells in the small intestine—dubbed neuropod cells—that synapse directly onto the vagus nerve, creating a rapid electrochemical line of communication between gut and brain.

Most recently, a 2026 study published in News-Medical provided the most startling evidence yet: specific gut bacteria were detected traveling via the vagus nerve and arriving in the brain tissue of mice—without any detectable breach of the blood-brain barrier.

Researchers confirmed that mice that underwent vagotomy (surgical severing of the vagus nerve) showed approximately twenty-fold fewer bacteria in the brain than control animals.

This architecture has profound implications for understanding both human perception and philosophy.

Within the labyrinthine walls of the digestive tract lies a complex neural empire — the Enteric Nervous System (ENS) — housing between 200 and 600 million neurons and over twenty distinct neuron types. This structure, embedded from esophagus to anus, does not merely process food.

It processes experience itself.

Johns Hopkins Medicine has called it “a brain in your gut” that is “revolutionizing medicine’s understanding of the links between digestion, mood, health, and even the way you think”.

Carl Jung, who spent decades mapping the dark corridors of the unconscious psyche, may have identified the psychological phenomenon; modern neurogastroenterology is now identifying its biological substrate.

When Jung declared that the unconscious would direct one’s life until it was made conscious, he was articulating, in the language of depth psychology, something that biochemistry is now expressing in the language of microbial signaling.

The second brain of the gut — and the trillions of microorganisms that colonize it — operates largely below the threshold of conscious awareness, shaping emotions, steering decisions, and sculpting personality in ways the thinking mind rarely suspects.

The ENS operates with a degree of independence that is neurologically extraordinary: studies confirm that even when the vagus nerve — the primary neural highway connecting gut to brain — is severed, the enteric nervous system continues to function autonomously.

The intestine, it has been noted, is the only organ in the body capable of operating in complete independence from the central nervous system.

This autonomy carries staggering implications. The standard model of human cognition places the brain at the center of all meaningful processing.

Yet neurogastroenterology reveals a rival headquarters operating in the abdomen, one that communicates with the central nervous system through bidirectional chemical and electrical signals transmitted via the vagus nerve within milliseconds.

As the University of British Columbia’s Neuroscience division observed, “emerging evidence is showing that the gut-brain axis is one of the most powerful relationships in our body”.

The gut is not merely reactive; it is generative. It initiates biochemical states that rise upward into consciousness and are experienced as emotion, motivation, and judgment — before the conscious mind has time to deliberate.

The Microbial Directors of Fate

Beyond the ENS itself lies a still deeper layer of hidden sovereignty: the microbiome. The human gut harbors trillions of microorganisms — bacteria, fungi, archaea, and viruses — that collectively outnumber human cells tenfold.

These microorganisms are not just passive passengers – they may be driving the human vehicle for billions of people around the globe.

A 2018 study published in Translational Psychiatry documented the first evidence that probiotic administration produced measurable changes in brain activation patterns during emotional memory and decision-making tasks — changes verified through functional MRI, alongside parallel shifts in gut microbiome composition and self-reported behavior.

The gut was not merely reflecting mental states.

It was reshaping them.

A landmark 2025 review published in PubMed confirmed that “gut microbiota play a foundational role in shaping emotional and cognitive functions through complex neuroimmune and neuroendocrine mechanisms,” modulating neurochemical pathways involving serotonin, dopamine, GABA, and glutamate.

These are not peripheral chemicals.

They are the very molecules of human consciousness, motivation, pleasure, and fear.

A landmark study published in Frontiers in Psychiatry examined 206 women and found that specific emotion-related factors — both positive and negative emotions and the strategies used to regulate them — were significantly associated with the composition of the gut microbiome at the species and metabolic pathway levels.

What a person feels, and how they manage those feelings, correlates directly with what microorganisms are active in the gut.

The causal relationship, as the evidence increasingly indicates, runs in both directions: emotional states alter the microbiome, and the microbiome alters emotional states.

The most arresting single statistic in this field is one that fundamentally reframes the Jungian question of unconscious control.

Approximately 90 to 95 percent of all serotonin in the human body is synthesized in the gut, not the brain.

In other words, the microbes living below conscious awareness produce the very neurotransmitters through which moods are experienced and decisions are made.

The gut’s microbial tenants are not merely influencing the human host.

In a very measurable biochemical sense, they are generating the chemical preconditions for what the host will call happiness, despair, aggression, or calm.

To call this “fate” — as Jung’s formulation predicted — is not poetry.

It is accurate phenomenology.

In this light, the Gnostic understanding of the body as a site of both bondage and liberation takes on a precise scientific meaning.

The microorganisms within the gut are not neutral bystanders.

They are active agents in the psychodrama of consciousness — and until their influence is recognized, it operates as fate.

To ignore this subterranean intelligence is not merely an oversight.

It is a surrender of agency.

Ancient Philosophy

Long before MRI scanners, neuroscience and cognitive psychology, ancient wisdom traditions had attempted to conceptualize the importance of impulse control and a disciplined mind.

Gnostic texts, Stoic philosophy, and Eastern metaphysics all grappled with what happens when the lower faculties of mind override the higher.

For the ancient Greeks and Romans, the body was never merely a machine. It was a microcosm mirroring the ordered cosmos itself.

Hippocrates of Kos (c. 460–370 B.C.) articulated medicine as a discipline rooted in observation of the whole patient — their diet, their climate, their emotional life, and their relationship to nature.

His famous aphorism, “It is more important to know what sort of person has a disease than to know what sort of disease a person has,” was not metaphor. It was clinical doctrine.

The Stoics called impulsive, unreflective reaction pathe — passions or disturbances that hijack the rational soul. The used sōphrosynē (temperance/self-mastery), which encompassed self-control, discipline, and modesty.

This was accomplished by mastering prosochē — “attention” or watchfulness over one’s own mind — as a kind of disciplined self-surveillance.

Epictetus taught in the Enchiridion that humanity’s suffering arises not from events themselves, but from undisciplined first reactions to those events.

Marcus Aurelius wrote extensively in the Meditations about the discipline required to pause between stimulus and response — a practice that presupposes the natural human tendency to not pause.

In Gnostic cosmology, the material world — the realm of raw sensation and reactive impulse — is governed by the Demiurge, a lesser creator-deity who mistakes surface reality for ultimate truth.

The pneumatic individual (the awakened Gnostic) transcends this reactive layer through gnosis — direct, experiential knowledge that moves beyond the sensory and the habitual.

From this perspective, the person who acts entirely before thinking is someone still imprisoned in the Demiurge’s domain: driven by sensation, reflex, and unexamined programming rather than by illuminated understanding.

When the Gnostic declared that true knowledge was felt as much as it was thought, they were not speaking metaphorically.

The gut feeling, the visceral intuition, the bodily knowing that precedes rational explanation—these were understood by ancient initiates to be forms of intelligence in their own right.

Modern neuroscience, through 200 to 600 million neurons embedded in the gut wall and a vagal communication highway that speaks predominantly upward, has arrived at the same conclusion through an entirely different path.

Galen of Pergamon (129–216 A.D.) extended this holism into an elaborate psychophysiology. Drawing on Platonic and Stoic philosophy, Galen argued that the soul possessed distinct faculties — rational, spirited, and appetitive — each governing different bodily systems.

In his On the Passions and Errors of the Soul, he proposed a system of emotional management rooted in metriopatheia (moderation of passions), arguing that the cultivation of emotional discipline had direct, measurable consequences on physical health.

His insights into the mind-body relationship marked what modern scholars recognize as the earliest systematic exploration of psychosomatic medicine, arguing that emotional states — grief, anger, love — could influence physical health as surely as diet or injury.

Conclusion

The science of the gut-brain axis does not simply offer new treatments for digestive disorders. It demands a fundamental revision of what it means to be a thinking, perceiving human being. The body is not a vehicle for the brain—it is a partner in consciousness.

Protecting the microbiome through diet, managing vagal tone through breath and contemplative practice, and understanding that emotional states are as much a product of the gut as of the mind are no longer alternative ideas.

They are supported by Columbia University, Johns Hopkins, Duke University, Stanford, and the pages of Nature.

As the ancient physicians and philosopher’s knew, and as modern science is rediscovering: to understand and control the mind, you must first understand and control the gut.

Hence, as Jung said, “Until you make the unconscious, conscious, it will direct your life and you will call it fate.”

References

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  2. Moore, Alison M., Manon Mathias, and Jørgen Valeur, eds. Gut-Brain Axis in History and Culture. Academia.edu, 2019. https://www.academia.edu/41210437

  3. Breit, Sigrid, et al. “Vagus Nerve as Modulator of the Brain–Gut Axis in Psychiatric and Inflammatory Disorders.” Frontiers in Psychiatry, 2018. https://pubmed.ncbi.nlm.nih.gov/29593576/

  4. Kaelberer, Maya M., et al. “A gut-brain neural circuit for nutrient sensory transduction.” Science, 2018. https://www.mbl.edu/news/thats-your-stomach-talking

  5. Morais, Livia H., et al. “The Microbiota-Gut-Brain Axis.” Physiological Reviews, 2021. https://www.academia.edu/59596278

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  7. “Gut-Brain Axis and Neurological Disorders—How Microbiomes Affect our Mental Health.” PubMed, 2022. https://pubmed.ncbi.nlm.nih.gov/36017855/

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  9. “Scientists show gut bacteria can reach the brain in mice via vagus nerve.” News-Medical, 2026. https://www.news-medical.net/news/20260315

  10. Gershon, Michael D. The Second Brain. Harper, 1998. https://www.goodreads.com/book/show/636974

  11. Cryan, John F., and Ted Dinan. Brain-Gut-Microbiota Axis Review, via Academia.edu trauma journal, 2018. https://www.academia.edu/36630794

  12. Physiology Society: “All Disease Begins in the Gut.” https://www.physoc.org/blog/food-for-thought-all-disease-begins-in-the-gut/

  13. Barnstone, Willis, and Marvin Meyer, eds. The Gnostic Bible. Shambhala, 2003. https://classicalastrologer.com/wp-content/uploads/2012/12/the_gnostic_bible.pdf

  14. Copenhaver, Brian P., trans. Hermetica: The Greek Corpus Hermeticum. Academia.edu. https://www.academia.edu/44747653

Carl Jung’s Shadow: The Secrets of Psychological Sovereignty & Free Will

Carl Jung’s Shadow: The Secrets of Psychological Sovereignty & Free Will

Perhaps one of Carl Gustav Jung’s most famous quotes was “Until you make the unconscious conscious, it will direct your life and you will call it fate.”

The quote was a declaration about the secrets of psychological sovereignty, free agency and free will.

Jung was not speaking metaphorically about mystical fate; he was making a clinical, structural argument about how the psyche operates when left unexamined.

He identified the unconscious with the Shadow in his work Aion as a “highly emotional, driven by primal instinct, often violent, and usually concealed from the social world by the conscious mind”.

Jung said that “the shadow personifies everything that the subject refuses to acknowledge about himself.” (CW 9i, para. 513) and he tells us, “Everyone carries a shadow.”

He claimed that it was the sum of all repressed, unintegrated, and disowned contents of the psyche — “highly emotional, driven by primal instinct” and “usually concealed from the social world by the conscious mind”.

The person who does not confront repressed grief will unconsciously engineer relationships that reproduce it.

The person unaware of deep-seated shame will self-sabotage success before it can expose them.

The person carrying unacknowledged rage will attract conflict wherever they walk—and call it bad luck.

Jung described the Shadow as driving individuals into repetitive, unconsciously motivated patterns — behaviors they would disavow if confronted with them consciously.

We become unconscious automatons.

This is the operative word: automatons.

Without self-knowledge, behavior becomes mechanical, reactive, and patterned—the very definition of a life directed not by free will, but by invisible compulsion wearing the costume of fate.

When we do not come to know and understand our own darkness or evil natures, we falsely project them into the world upon other people and our neighbors.

Jung says, “When an individual makes an attempt to see his shadow, he becomes aware of (and often ashamed of) those qualities and impulses he denies in himself but can plainly see in other people . . .such as egotism, mental laziness, sloppiness, unreal fantasies, schemes, plots, carelessness, cowardice, inordinate love of money and possessions . . . in short, all the little sins about which he might previously have told himself: “that doesn’t matter”. (P. 174)

Sigmund Freud, Jung’s famous intellectual predecessor and rival, established the foundational clinical case. He described the unconscious as;

“A reservoir of repressed feelings, traumatic memories, and instinctual drives that remain hidden from awareness yet exert profound influence over emotion and decision-making,” and declared that “the majority of human behavior originates not from rational, conscious thought, but from deep-seated inner conflicts and instinctual forces operating beyond our awareness or control”.

Indeed, Freud’s stated goal for psychoanalysis was identical to Jung’s: to make the unconscious conscious.

According to Jung, “We carry our past with us, to wit, the primitive and inferior man with his desires and emotions, and it is only with an enormous effort that we can detach ourselves from this burden.

If it comes to a neurosis, we invariably have to deal with a considerably intensified shadow.

And if such a person wants to be cured it is necessary to find a way in which his conscious personality and his shadow can live together.” (Answer to Job)

Jung stated that a human being deals with the reality of the shadow in four ways: denial, projection, integration and/or transmutation.

The goal is always the latter – integration and transmutation.

The unconscious is not all darkness and evil.

Jung was explicit that the Shadow also contains “normal instincts, appropriate reactions, realistic insights, creative impulses” that have been denied their rightful place in the personality.

Jung claimed that not only do our evil tendencies arise our unconscious behaviors projected through our shadow, but also our good qualities. He writes;

“If it has been believed hitherto that the human shadow was the source of all evil, it can now be ascertained on closer investigation that the unconscious man, that is, his shadow, does not consist only of morally reprehensible tendencies, but also displays a number of good qualities, such as normal instincts, appropriate reactions, realistic insights, creative impulses, etc.” (Carl Jung, CW 9ii, Para 423)

As Jung warns “If you get rid of qualities[of the Shadow] you don’t like by denying them, you become more and more unaware of what you are, you declare yourself more and more non-existent, and your devils will grow fatter and fatter.” ~Carl Jung, Dream Analysis, Page 53.

Jung taught that one does not become enlightened by imagining figures of light, but by making the darkness conscious.

This process helps integrate the self with the unconscious.

The alchemical marriage of the shadow with the self.

Jung had said, “Knowing your own darkness is the best method for dealing with the darknesses of other people.”

Once we have self knowledge of our own darkness, we can stand as true arbitrators and rulers of our fates.

Captains of our lives, rather than passengers along for the ride.

According to Jung, “To confront a person with his shadow is to show him his own light.

Once one has experienced a few times what it is like to stand judgingly between the opposites, one begins to understand what is meant by the self.

Anyone who perceives his shadow and his light simultaneously sees himself from two sides and thus gets in the middle.” (Good and Evil in Analytical Psychology)

Jung had written, “If you imagine someone who is brave enough to withdraw all his projections, then you get an individual who is conscious of a pretty thick shadow. Such a man has saddled himself with new problems and conflicts.

He has become a serious problem to himself, as he is now unable to say that they do this or that, they are wrong, and they must be fought against…

Such a man knows that whatever is wrong in the world is in himself, and if he only learns to deal with his own shadow he has done something real for the world.

He has succeeded in shouldering at least an infinitesimal part of the gigantic, unsolved social problems of our day.” (Psychology and Religion)

It is important to understand that Jung implies that the goal is not to repress our unconscious or deny the shadow, to do so would make our shadow revolt and cause us problems.

He also warns us not to misunderstand and or repress our dark side.

Jung said, “Whether our shadow becomes our friend or enemy depends largely upon ourselves. The shadow becomes hostile only when he is ignored or misunderstood.” (Man and His Symbols)

He further warns us, “The educated man tries to repress the inferior man in himself, not realizing that by so doing he forces the latter into revolt.”

Jung believed people become enlightened when they understand their unconscious mind and accept the darker parts of themselves, ie their shadows. By doing so, each awakened person becomes a unique individual – an authentic being who has a distinct and possibly predetermined destiny.

This is no easy task and Jung makes it clear that it takes a lot of honest self-examination, courage, and work to face and integrate one’s shadow into their life. Jung writes;

“The discovery of the unconscious is one of the most far-reaching discoveries of recent times. But the fact that recognition of its unconscious reality involves honest self-examination and reorganization of one’s life causes many people to continue to behave as if nothing at all has happened.”

He says, “It takes a lot of courage to . . . tackle the problems it raises. Most people are too indolent to think deeply about even those moral aspects of their behavior of which they are conscious; they are certainly too lazy to consider how the unconscious affects them.”

Science Confirms the Jung’s Unconscious & Shadow Theories

Modern neuroscience and cognitive psychology have quietly confirmed Jung’s diagnosis of the unconscious aspects of the human psyche — without giving credit or mentioning Jung.

A landmark 2008 study by Soon, Brass, Heinze, and Haynes, published in Nature Neuroscience, demonstrated that brain activity predicting a conscious decision could be detected up to ten seconds before the subject was aware of having made a choice.

The brain, in other words, acts before the mind knows it has decided.

The unconscious directs behavior; consciousness merely ratifies it afterward.

Cognitive psychologist Gerald Zaltman of Harvard Business School has estimated, based on decades of consumer and behavioral research, that “ninety-five percent of thought, emotion, and learning occur in the unconscious mind—that is, without our awareness”.

If accurate, this means the conscious “I” that plans, deliberates, and makes choices is engaging with only a fraction of the forces actually governing behavior.

Contemporary researchers at Frontiers in Psychology (2025) have confirmed that brain-based machine learning models can decode unconscious image processing and behavioral tendencies from neural data, even when subjects report no awareness of the stimuli—demonstrating that rich cognitive processing occurs entirely below the threshold of consciousness.

The British Psychological Society has further noted that “much of modern cognitive psychology and the neurosciences is consistent with the Freudian view that behavior can become automatized through repetition, and that the control of such behavior is devolved to autonomous or semi-autonomous unconscious structures”.

When Jung declared that the unconscious would direct one’s life until it was made conscious, he was articulating, in the language of depth psychology, something that biochemistry is now expressing in the language of microbial signaling.

The second brain of the gut — and the trillions of microorganisms that colonize it — operates largely below the threshold of conscious awareness, shaping emotions, steering decisions, and sculpting personality in ways the thinking mind rarely suspects.

A landmark 2025 review published in PubMed confirmed that “gut microbiota play a foundational role in shaping emotional and cognitive functions through complex neuroimmune and neuroendocrine mechanisms,” modulating neurochemical pathways involving serotonin, dopamine, GABA, and glutamate.

These are not peripheral chemicals.

They are the very molecules of human consciousness, motivation, pleasure, and fear.

What science is telling us is that the unconscious is ruled by these microorganisms who also control what Jung called the shadow.

The microorganisms within the gut are not neutral bystanders.

They are active agents in the psychodrama of consciousness — and until their influence is recognized, it operates as fate.

Jung’s prescription for liberation from the unconscious was individuation — the deliberate, disciplined process of bringing hidden contents into awareness, integrating the Shadow, and achieving psychological wholeness.

The process of liberation Jung prescribed is known as individuation—the lifelong journey of integrating the Shadow and all other unconscious contents into a unified, conscious Self.

Carl Jung had written in Two Essays on Analytical Psychology:

“Individuation means becoming an “in-dividual,” and, in so far as “individuality” embraces our innermost, last, and incomparable uniqueness, it also implies becoming one’s own self.

We could, therefore, translate individuation as “coming to selfhood” or “self-realization.”

In order to reach selfhood and not become possessed, ignorant or go mad, (controlled by their Shadow), we must have a friendly encounter with our own demon and get to know him or her.

A process that represented an archetypal stage of self individuation.

Shadow work, the practical expression of individuation, is described by contemporary Jungian therapists as “the attempt to make these less desirable aspects of ourselves conscious and to integrate them by acknowledging and making peace with them”.

The Philosophers Who Came Before

Jung did not speak into a vacuum. The philosophical lineage supporting this insight runs deep into antiquity.

Socrates delivered the ancient world’s equivalent over 2,400 years ago. His declaration—”The unexamined life is not worth living”—spoken at his own trial in Athens, was not rhetorical flourish.

Socrates believed, as Plato recorded in the Phaedrus, the Meno, and the Apology, that self-knowledge was the prerequisite for virtue, for justice, and for the good life.

One cannot act rightly from a self one does not understand.

His method of dialectical inquiry was, in essence, the ancient form of making the unconscious conscious.

Plato formalized this in his theory of the soul, arguing in the Republic that “the absence of knowledge is the cause of the individual’s liability to instability and moral degeneration”.

The shadows on the wall of Plato’s famous cave allegory are themselves a metaphor for unconscious projections—mistaking appearances driven by interior ignorance for reality itself.

Lao Tzu anticipated this millennia before Jung in the Tao Te Ching: “He who knows others is wise. He who knows himself is enlightened”.

The operative distinction is one of direction—inward versus outward.

All external mastery built on interior ignorance is mastery of illusion.

For readers of Gnostic tradition and hidden knowledge, Jung’s dictum resonates with remarkable precision against ancient frameworks.

The Gnostic concept of gnosis—direct, experiential self-knowledge that pierces the veil of illusion—is structurally analogous to Jungian individuation.

The Demiurge of Gnostic cosmology, the false creator who imprisons the divine spark in ignorance, functions in psychological terms as the unexamined unconscious: a hidden force shaping reality while the individual believes themselves free.

The alchemical texts Jung spent decades studying spoke of the nigredo—the blackening, the confrontation with the shadow material—as the necessary first stage of transmutation.

One cannot reach gold without first descending into darkness.

As Jung himself noted in his lectures: “If man does not reverence and submit to the unconscious, which created his consciousness, he loses his soul, that is, he loses his connection with soul and unconscious”.

This is not metaphor for Jung—it is structural psychology expressed in the symbolic language available to modern minds.

He said the only way for someone to get in the middle is through knowledge of the self which leads to understanding our own good and evil natures and by doing so, we learn how to reason with ourselves and others which leads to the light ie: true wisdom of the world in which we live.

This newfound wisdom allows us to integrate our modern lives that are often governed (molded) outwardly by our unconscious world ie: parents, government, community and culture with the inner Self which then becomes the true archetype of wholeness and self-transcendence.

An enlightened person who understands the light and darkness in themselves and also in others but stands in the middle using reason to transcend our self made prejudices and boundaries

The person who has integrated with his or her shadow no matter the era always seems to become a beacon of light for humanity helping answer life’s most difficult questions and confronting the monsters that many of us who are too afraid to confront our own shadows.

The universal image is the Hero and the end result of this Great Work no matter the race or culture is that immortal person whom we have all come to love and adore.

In this Age-old saga, we will forever see the visions of the Great Shadow of the Swiss Gnostic Hero – Carl Jung forever bringing light to those who fear their own darkness.

Conclusion

Carl Jung understood that what a person cannot see within themselves will rule them from without.

He created a diagnostic principle—a map of exactly how human beings become prisoners of patterns they mistake for providence.

The unconscious does not announce itself.

It does not declare its influence.

It simply acts, and the unaware individual experiences the results as the story of their life.

Ancient philosophers from Socrates to Lao Tzu demanded self-knowledge as the foundation of human dignity.

Freud and Jung transformed that demand into clinical science.

Modern neuroscience has now quantified the scale of unconscious governance of behavior.

The second brain acting as our unconscious master is not a metaphor.

While ancient myths, sacred texts, and Gnostic cosmologies may strike the modern atheist or committed skeptic as mere allegory or superstition, the psychological and biological sciences have begun to vindicate what the ancients encoded in symbol and story.

These narratives were never simply fantastical — they were maps of the human condition.

Carl Gustav Jung spent a lifetime demonstrating that the unconscious is not a metaphor but a measurable, operative force shaping thought, behavior, and destiny.

His concept of the shadow — the unintegrated, unacknowledged dimension of the psyche — functions as a tyrant operating beneath awareness, steering choices its host never consciously makes.

This is not poetry.

It is psychology with profound implications for human freedom, a freedom humanity has been struggling to reclaim across millennia.

The parallels with Gnostic cosmology are not incidental.

The Gnostic Demiurge — most famously rendered as Yaldabaoth, the blind and arrogant craftsman-god who imprisons divine sparks in material flesh — maps with striking precision onto Jung’s unconscious shadow.

Both are described as domineering, self-serving forces that operate invisibly, convincing their subjects that no higher authority exists.

The imprisoned Gnostic soul and the shadow-dominated ego suffer the same essential condition: captivity mistaken for freedom.

As Jung himself wrote, “Until you make the unconscious conscious, it will direct your life and you will call it fate.”¹

The modern Gnostic path demands not only the examined mind, but the examined gut — and the disciplined intervention required to ensure that microbial fate becomes conscious choice.

The convergence is undeniable: the examined self is not a luxury of the philosophically inclined—it is the prerequisite for authorship of one’s own life.

Until that examination is undertaken, fate is not written in the stars.

It is written in the dark (nigredo of your gut).

The Ultimate Solution

I will leave you with what I believe Jung’s final prophetic solution to conquer the demons of our modern era;

“I have already suggested that the only salvation lies in the piecemeal work of educating the individual. That is not as hopeless as it may appear. The power of the demons is immense, and the most modern media of mass suggestion – radio, film, etc. — are at their service.

But Christianity, too, was able to hold its own against an overwhelming adversary not by propaganda and mass conversions — that came later and was of little value — but by persuasion from man to man.

And that is the way we also must go if we wish to conquer the demons.”

References

    1. Jung, C. G. Aion: Researches into the Phenomenology of the Self. Princeton: Princeton University Press, 1959. https://www.gnosticwarrior.com/jungs-shadow.html

    2. Jung, C. G. CW 9ii, Para 423 — The Shadowhttps://www.gnosticwarrior.com/jungs-shadow.html

    3. “Jungian Psychology: Unraveling the Unconscious Mind.” Positive Psychologyhttps://positivepsychology.com/jungian-psychology/

    4. “Shadow Work and Jungian Psychology in Contemporary Therapy.” IJSREM, 2025. https://ijsrem.com/download/shadow-work-and-jungian-psychology-in-contemporary-therapy-reclaiming-the-disowned-self/

    5. “Shadow, Self, and Regulation: A Jungian Contribution to Emotional Intelligence Theory.” Academia.eduhttps://www.academia.edu/129362819/Shadow_Self_and_Regulation_A_Jungian_Contribution_to_Emotional_Intelligence_Theory

    6. “The Jungian Shadow and Self-Acceptance.” Texas A&M University at Galveston, Nautilus. https://www.tamug.edu/nautilus/articles/The%20Jungian%20Shadow%20and%20Self-Acceptance.html

    7. Soon, C.S., Brass, M., Heinze, H.J., & Haynes, J.D. “Unconscious determinants of free decisions in the human brain.” Nature Neuroscience 11, 543–545, 2008. https://scholar.google.com/citations?user=GCMhq8MAAAAJ&hl=en

    8. “Freud’s Theory of the Unconscious Mind: The Iceberg Analogy.” Simply Psychology, 2024. https://www.simplypsychology.org/unconscious-mind.html

    9. “New Methods, Old Questions: Advancing the Study of Unconscious Processing.” Frontiers in Psychology, 2025. https://www.frontiersin.org/journals/psychology/articles/10.3389/fpsyg.2025.1626223/full

    10. “The Unexamined Life Is Not Worth Living.” Wikipedia. https://en.wikipedia.org/wiki/The_unexamined_life_is_not_worth_living

    11. “Knowing Ignorance in the Early Socrates: Self-Knowledge Delivers Virtuous Action.” Academia.edu. https://www.academia.edu/30596014

    12. “The Development of Self-Knowledge in Plato’s Philosophy.” Academia.edu, 2022. https://www.academia.edu/78190936

    13. “Nietzsche on the Embodiment of Mind and Self.” Academia.edu. https://www.academia.edu/3331665

    14. “Freud and the Unconscious.” British Psychological Society. https://www.bps.org.uk/psychologist/freud-and-unconscious

    15. Zaltman, Gerald. How Customers Think. Boston: Harvard Business School Press, 2003. Quoted at https://www.azquotes.com/quotes/topics/unconscious-mind.html

    16. Clarke, Gerard, et al. “The Microbiota-Gut-Brain Axis.” Neuropsychopharmacology Reviews, 2019. https://www.academia.edu/59596278/The_Microbiota_Gut_Brain_Axis
    17. Gershon, Michael D. The Second Brain. New York: HarperCollins, 1998.
    18. Hopkins Medicine. “The Brain-Gut Connection.” Johns Hopkins Medicine. https://www.hopkinsmedicine.org/health/wellness-and-prevention/the-brain-gut-connection
    19. Lach, Gilliard, et al. “The Gut-Brain Axis: Influence of Microbiota on Mood and Mental Health.” Integrative Psychiatry, 2019. https://pmc.ncbi.nlm.nih.gov/articles/PMC6469458/
    20. Mukherjee, Ananya, et al. “The Gut Microbiome and Its Impact on Mood and Decision-Making.” PubMed/PMC, 2025. https://pmc.ncbi.nlm.nih.gov/articles/PMC12609437/
    21. Pearson-Leary, Jiah, et al. “Gut Microbiota Regulates Key Modulators of Social Behavior.” PubMed, 2016. https://pubmed.ncbi.nlm.nih.gov/26613639/
The Scent of Illness and Death: The smell of fungi eating rotting humans

The Scent of Illness and Death: The smell of fungi eating rotting humans

Fungi or molds are the true ouroboros of nature.

After all, fungi eat illness and death, and in doing so, create new life.

I find the concept of fungi controlling the cycle of destruction and creation highly intriguing. I often ponder the biological processes that govern these laws of nature and their filamental connections to human beings.

In my capacity as a certified mold inspector and remediator based in the United States, I am well-versed in identifying mold (fungal) infestations in homes. These infestations often manifest as a specific odor reminiscent of decaying construction materials.

Repeated exposure to this distinctive scent has honed my detection skills over the span of a decade, allowing me to identify it with almost flawless accuracy.

The other day, it occurred to me: Wouldn’t humans with fungal infections or diseases produce a similar scent of decay or rot?

A brief online investigation confirmed my hypothesis!

Many studies have shown that humans demonstrate a proficient capacity to recognize and respond suitably to scent signals indicating danger such as certain chemicals resulting from biological decay processes to evoke avoidance (Rozin et al. 2000). Researchers have found that certain volatile compounds or smell hazards can be divided into two categories based on the human emotions associated with microbial threats (e.g., organic decay, vomit or feces) and nonmicrobial hazards (e.g., predators, fire, degraded air, and poisons).

For example, the smell of smoke would elicit fear that a fire is nearby and you need to move away or flee the area, while the smell of rotting garbage or moldy drywall will cause a disgusting emotion as the person inhales these VOCs. The reason is studies have shown that each class of threats is associated with a different underlying emotion such as disgust or fear/panic, which could indicate the level of threat.

This powerful smell detection system in animals and humans serves as an evolutionary defense mechanism deeply ingrained in our subconscious minds over millennia. The scents of decay, emanating as volatile compounds, serve as environmental cues for all living beings, including microorganisms, animals, and humans.

When we inhale, these odor molecules travel through the nasal passages and reach the olfactory epithelium, where they bind to the receptor proteins. This triggers a series of chemical signals that are sent to the brain, specifically the olfactory bulb, which processes and interprets the information to identify the scent.

While some scents signal the presence of food, others indicate potential threats such as predators, pathogens, fires, or even kin relationships.

Researchers have found that many individuals have reported experiencing a distinct change in their sense of smell when they or a loved one falls ill. This phenomenon is not merely coincidental; rather, it is rooted in the intricate connections between our olfactory system and our overall health.

I know this smell all too well.

When I was a young teen serving out my community service sentence in a senior citizen home, I could vividly remember this distinct smell as I walked down the lonely concrete halls.

This smell was not pleasant. It was a mixture of urine, feces, and rotting flesh.

As I served out my 30-day sentence, I felt every time I walked into that facility that I was walking on a narrow ridge between the shadow of the valley of death and life.

The next time I came across this unique scent again was in the ICU room of a hospital when my father had almost died from alcoholism at 52.

As I watched the nurses pump the shit out of his blood as he lay there incapacitated and near death because his liver gave out, that strange smell hit my nostrils bringing back memories of the nursing home.

Again, I realized where I was.

But this time I was a visitor witnessing my father’s life being dragged into the valley of death. As if they had, the legions received a notice of his impending doom coming to feast on his barely living carcass.

Today as I look back, I’m much more educated about human biology, health, disease, and death. As it relates to the scent of death, I have found an interesting correlation that explains this phenomenon.

What I found is that scent can be a powerful indicator of understanding the science of illness and death.

THE SCIENCE OF THE SMELL OF DISEASE

Our sense of smell, also known as olfaction, is a powerful and often underappreciated sense that plays a crucial role to detect and differentiate between a vast array of scents, from the pleasant aroma of freshly baked cookies to the pungent odor of rotten eggs and even infectious diseases.

Clinicians have long recognized that most infections produce distinctive odors associated with a particular disease. In fact, each disease has a specific smell that is almost always associated with a rotten or decaying scent as if we are slowly being eaten alive, which appears to be the case.

In the human body, microbial organisms generate a variety of volatile substances, and different smelly compounds like alcohols, aliphatic acids, and terpenes. Research into the emission of VOCs resulting from microbial activity in bodily fluids and organs, which are then released through breath, urine, feces, and sweat traces back to the early 1800s.

The reason is that beyond exhaling air, your breath contains volatile compounds (VOCs) originating from various bodily organs that act as environmental signals (magnets) to nearby predators, pathogens, and kin.

If we have a fungal disease in one of our organs, they will emit these VOCs through our breath, sweat, skin, urine, feces, and vaginal secretions. But our blood is the most important source for these pheromone signals in the form of bodily odors.

For example, it’s common to experience morning breath, particularly if you’ve slept with your mouth open. However, bad breath or halitosis can also be a sign of underlying health issues such as gum disease, respiratory infections, or even digestive problems.

Persistent bad breath that doesn’t improve with regular oral hygiene measures like brushing and mouthwash could indicate an underlying issue such as infections in the sinuses, throat, or lungs, requiring medical attention from a healthcare professional.

When we smell these odors of other people, they are called pheremones which are small volatile organic molecules that animals and humans use to communicate. Pheromones are clinically defined as “substances which are secreted to the outside by an individual and received by a second individual of the same species, in which they release a specific reaction, for example, a definite behavior or a developmental process”.

Pheromones play a critical role in signaling and choreographing interactions between fungi mating partners during sexual reproduction.

Meaning, that certain smells give off a magnetic cue for fungi within the human body that they should start having lots of sex and reproduce more offspring, which would require that the increased fungal population needs more food to feast upon.

My theory is that this increased fungal load creates fermentation within our blood and organs which morphs this symbiotic relationship into a parasitic one leading to illness, disease, and eventually death. These illnesses caused by fermentation create a unique rot or decaying odor that we have the innate ability to detect.

Interestingly, I have found that research has revealed that certain illnesses can alter a person’s body odor, making them emit distinct pheromone scents that can be detected by others, even at a subconscious level. This ability to detect sickness through pheromones may have evolved as a survival mechanism, allowing us to avoid contact with individuals who are ill and reducing the risk of spreading disease within a community.

For example, researchers have found that certain infections like tuberculosis can create a unique odor in the patient’s sweat and even metabolic disorders such as phenylketonuria can result in a musty odor in the individual’s breath or skin. A fruity or rotten apple-like odor might indicate poorly controlled diabetes.

In some cases, organ failure can contribute to bad breath. Kidney failure, for instance, may produce an ammonia or urine-like odor, while serious liver disease can result in musty or garlic-like breath.

Another notable example is the use of scent analysis to detect early signs of certain types of cancer through breath samples. By analyzing the volatile organic compounds present in exhaled breath, researchers have been able to identify specific scent markers associated with different types of cancer, enabling early detection and intervention.

SMELL OF DEATH

Our olfactory senses have the remarkable ability to detect subtle changes in the body’s chemistry, even after passing. The unique scents that accompany different stages of decomposition can provide valuable insights into the time of passing and the processes at play within the body.

Before death, the human body undergoes a fascinating series of changes that can be detected through various senses, including smell. When a person is diseased or near death, the breakdown of cells and tissues initiates a complex biochemical process that releases volatile organic compounds (VOCs) into the surrounding environment. These VOCs are responsible for the unique pre and post-mortem scent that evolves.

Initially, the absence of vital functions such as circulation and respiration leads to a lack of oxygen supply to cells, resulting in anaerobic metabolism and the production of compounds like putrescine and cadaverine. These compounds contribute to the characteristic early-stage scent of death, often described as sweet and sickly.

As time progresses, microbial activity intensifies, causing further decomposition and the release of additional VOCs such as skatole and indole. These compounds give rise to the distinctive foul odor associated with the beginning stages of decomposition.

When a living organism ceases to function, a complex series of biological processes begin to unfold, leading to the breakdown of tissues and the release of various gasses and compounds.

The stages of decomposition can be broadly categorized into fresh, putrefaction, decay, and dry remains.

During the fresh stage, the body undergoes immediate changes such as algor mortis (cooling of the body), rigor mortis (stiffening of muscles), and livor mortis (discoloration of the skin due to pooling of blood). As the process progresses into putrefaction, bacteria within the body begin to break down tissues, releasing volatile organic compounds that contribute to the characteristic odors associated with decomposition.

Moving into the decay stage, the body continues to break down, leading to the formation of adipocere (a waxy substance) and further release of gasses such as methane and hydrogen sulfide. Finally, the remains enter the dry stage, characterized by the mummification of tissues and a reduction in odor production.

Studies have shown that as the body undergoes the process of decomposition, distinct scents are released that can provide valuable insights into the timeline of when an individual passed away.

One notable case study involved analyzing the volatile organic compounds (VOCs) emitted during decomposition. Researchers found that specific compounds, such as putrescine and cadaverine, increased in concentration over time, creating a unique scent profile associated with different stages of decomposition.

Health factors also play a crucial role in influencing post-mortem scent. Various health conditions and medications can impact the decomposition process and alter the odor profile after death. For example, individuals with certain illnesses may produce distinct chemical compounds during decomposition, leading to unique and identifiable post-mortem scents.

Researchers found that dying cells might signal their demise to nearby living cells by releasing specific metabolites, potentially orchestrating physiological responses to stress. Through mass spectrometry analysis of intracellular and extracellular metabolomes, they identified five metabolites involved in the process.

Additionally, they found adenosine triphosphate, previously known for its role in immune cell recruitment, to be upregulated after apoptosis induction. Importantly, the release of these metabolites was reduced when cells were treated with a pan-caspase inhibitor, suggesting that apoptotic cells actively release biologically relevant metabolites.

The authors explored whether metabolites released by dying cells were just incidental or reflect the cell’s activity before death. They found that spermidine levels were notably high in all models tested.

Spermidine is a naturally occurring polyamine that is present in various foods such as soybeans, wheat germ, and aged cheeses. In mammalian cells, spermidine is produced from putrescine, which is derived from ornithine, or through the oxidative breakdown of spermine.

It can also be taken up from the extracellular environment or expelled from the cell, potentially through membrane transporters akin to those found in yeast and bacteria, or through endocytosis/exocytosis mechanisms.

Spermidine is produced from putrescine.

A word that means “becoming putrid or rotting.”

This is the decomposition of carbon matter.

The scent of death.

Putrescine is found in all organisms and plants.

Its role is well documented to play a role in stress responses in plants and its absence is associated with an increase in both parasite and fungal populations in plants. It is what causes bad breath and vaginosis. Putrescine is found in semen and some microalgae, together with spermine and spermidine.

The intestinal microbiota represents the main source of spermidine synthesis within our body.

Studies of mice found that the concentration of spermidine in the gut lumen could be upregulated through oral administration of probiotics and the amino acid arginine, resulting in suppressed inflammation and improved longevity in old mice.

Due to its role in putrification, elevated putrescine has also been proposed as a biochemical marker for determining how long a corpse has been decomposing and also premortem diseases such as cancer. Scientifically speaking as it relates to humans, putrefying tissue of dead bodies breaks down our cells and proteins which undergo anaerobic splitting by bacteria and fungi creating a pungent scent that is emitted by putrescine.

Research on animals shows that it can function as a powerful chemosensory signal that prompts the perceiver to leave or avoid the area and that humans can identify threats via chemosignals. This unique scent has been studied to activate what is known as a “chemosensory warning signal” within humans activating threat management responses (e.g., heightened alertness, fight-or-flight responses).

The significance of scent in this realm cannot be understated, as it opens up a new dimension in forensic science that can lead to more accurate diagnosis, estimations, and conclusions in pre and post-mortem investigations.

Advancements in technology are paving the way for more accurate and efficient methods of determining illness, disease, and death based on scent analysis.

One promising development is the use of electronic nose devices, which are designed to mimic the human sense of smell and can detect and analyze volatile organic compounds (VOCs) emitted during decomposition. These devices have the potential to provide rapid and objective assessments of post-mortem scent profiles, aiding forensic investigators in determining the time of passing with greater precision.

Additionally, research is underway to explore the use of artificial intelligence and machine learning algorithms to analyze complex scent data patterns and identify specific biomarkers associated with different stages of decomposition.

CONCLUSION

Understanding the intricate relationship between the science of the scent of illness and death can pave the way for advancements in the diagnosis and prognosis of people infected by fungi.

Our olfactory system can serve as a powerful tool in identifying early signs of infectious disease, human decay, and organ rotting found in various diseases.

As we’ve explored in this article, clinicians have long recognized and several studies prove that many infections produce distinctive odors associated with particular diseases.

The sense of smell, often overlooked in healthcare settings today, will play a significant role in detecting and monitoring illnesses in the future.

By harnessing the power of our sense of smell, healthcare professionals can potentially improve early detection, treatment outcomes, and overall patient care.

The implications for humanity could be profound.

SOURCES:

The scent of disease: volatile organic compounds of the human body related to disease and disorder – Oxford Academic

PUBMED: Humans can detect axillary odor cues of an acute respiratory infection in others

Pheromones and their effect on women’s mood and sexuality – PUBMED

Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin in humans?

The smell of death: evidence that putrescine elicits threat management mechanisms

An Initial Evaluation of the Functions of Human Olfaction

Adenosine Triphosphate (ATP): How Fungi Control the Global Energy Reserve of All Life

Adenosine Triphosphate (ATP): How Fungi Control the Global Energy Reserve of All Life

In the human body, adenosine triphosphate (ATP) is the primary energy currency for humans cells and also all living organisms from fungi to bacteria to plants and animals. Understanding the intricate role of ATP in cellular processes is crucial for comprehending the intricate mechanisms that drive life at a microscopic level.

ATP is classified as a nucleic acid and is composed of three fundamental components: adenine, a nitrogenous base; a five-carbon ribose sugar; and a triphosphate chain containing three phosphate groups.

The phosphate groups in ATP, known as alpha, beta, and gamma from closest to farthest from the ribose sugar, are linked by high-energy phosphoanhydride bonds.

Its structure, with high-energy phosphate bonds, allows for the storage and release of energy, which is the driving force behind the functionality of ATP. Upon the cleavage of these bonds, a surge of energy is released, propelling a myriad of cellular functions essential for the sustenance of living organisms.

When these bonds are broken, the release of energy fuels a myriad of cellular functions, enabling processes such as muscle contraction, nerve impulse transmission, and biosynthesis to occur efficiently.

Phosphates are complex compounds fundamental to all cells and help form and repair our DNA and RNA. Phosphate is an anion composed of phosphorous (P) and oxygen (O) atoms.

Phosphorous is an element whereas phosphate is an anion.

An anion is an ion with negative charge, meaning it has more electrons than protons.

It is important that we understand that all life on earth shares the elemental energy source of phosphorous. It is derived from Ancient Greek φωσφόρος (phōsphóros, “the bearer of light”), from φῶς (phôs, “light”) + φέρω (phérō, “to bear, carry”). In Latin, it is known as lucifer and is encoded in Scripture in the Book of Issah as “fallen from heavan.”

When a cell requires energy to carry out essential processes such as muscle contraction, active transport of molecules across membranes, or synthesis of macromolecules, it initiates the breakdown of ATP. Enzymes within the cell catalyze the hydrolysis of ATP by breaking the bond between the terminal phosphate group and the rest of the molecule.

This process results in the formation of adenosine diphosphate (ADP) and inorganic phosphate (Pi), along with the release of energy that was stored in the phosphoanhydride bond. The energy released powers the specific cellular activity that required it, allowing cells to perform tasks vital for their survival and function.

ATP is also known as a purine, which means it is one of two chemical compounds that cells use to make the building blocks of DNA and RNA. They are found in mainly in meat and meat products and are broken down by the body to form uric acid, which is passed in the urine.

Purines such as ATP and adenosine play a central role in the energy metabolism of all life forms. They are released from neurons and glial cells which produce widespread effects on multiple organ systems by binding to purinergic receptors located on the cell surface.

ATP is essential for various cellular processes, including brain function, muscle contraction, biosynthesis, and active transport processes in cells. Active transport involves the movement of molecules or ions against their concentration gradient, requiring energy input. It acts as an excitatory neurotransmitter in motor neurons of the spinal cord, as well as sensory and autonomic ganglia.

Through the cleavage of these phosphoanhydride bonds, ATP releases the energy needed to drive processes such as muscle contraction, nerve impulse transmission, protein synthesis, and various biochemical reactions within cells. This energy transfer mechanism not only sustains basic cellular functions but also enables organisms to grow, reproduce, and respond to environmental stimuli.

When this system is altered or is not getting and or recycyling an adequate amount of ATP through diet and excercise, then these processes become corrupt causing orgamisms such as humans to stop growing and able to respond adequately to environmental stimuli.

I contend that you physical and mental capacities enter into an automanous or sleep like state.

HOW DO WE CREATE ATP?

ATP is created when we eat food. Especially meat and dairy products.

When food is consumed, it undergoes digestion by our microbiome, i.e.: fungi and bacteria which we feed to break down our food into vitamins and ATP energy.

Without this community of microbes that lives symbiotically within and around us, we would not be able to break down the food we eat. Hence, we would simply not exist.

My contention is that this relationship can be compared to a master and slave being that we are slaves and they are our masters.

This is why they can become paraistic when we do not give these microbes the nutrients they require. As if there is an automantonus kill switch withit our cells that turns on when we digress againts these natursal laws. Instead of eating the good food we supply them with, they will eat us and the science proves this.

Let me explain how this happens…

ATP synthesis is the process by which ATP is produced, typically occurring in the mitochondria of eukaryotic cells through cellular respiration by our microbiome. During this process, energy is generated and stored in the form of ATP, ready to be used for various cellular functions.

With that said, it is not you and I who create this energy, but the fungi and bacteria within our guts.

This microbial energy is created by what scientists call, “ATP synthase.”

This means our microbiome rotates in a clockwise manner (like hydroelectric turbines) in response to eating food causing proton flow coupled with ATP synthesis to catalyze the conversion of Adenosine diphosphate (ADP) to ATP.

Here is a computer animation of this process that occurs within a “healthy human gastrointestinal tract.”

This quote from a team of scientists from Germany and Japan to summarize their study of ATP synthase:

“ATP synthase is an iconic intelligently designed molecular machine because of its rotary engine and its universal distribution. Similar forms of these rotating machines, one-tenth the size of the famous bacterial flagellum, are found in all animal cells, plant cells, bacteria, and archaea.

The precision machine raises a huge challenge to all origin-of-life theories: how could a working cell arise without these irreducibly complex molecular machines?

They are vital to every organism on earth.

I heard a biologist at JPL say that if they stopped working, we would be dead before we hit the floor.

For eukaryotic ATP synthase, there is a rotor and stator in the FO domain that turns a “crankshaft” to operate the F1 domain. In the F1 domain, three pairs of catalytic units combine ADP (adenosine diphosphate) with phosphate to produce ATP (adenosine triphosphate), the universal energy currency for most cellular processes.

A main purpose of the food we eat is to create a flow of ions to operate these machines.

ATP synthase is the last machine in a series of complexes in our mitochondria whose collective function is to donate electrons to various intermediates so that protons can be extracted. Protons accumulate between the mitochondrial membranes and flow into ATP synthases.

The machines are lined up in pairs along the folds of the mitochondria (cristae) to take advantage of the proton motive force. That flow of protons turns the FO domains like waterwheels, generating three ATP per revolution in the F1 domains, as shown in the animation.”

ADP can be converted back to ATP through a process called phosphorylation, in which a phosphate group is added back to the molecule using energy from other cellular processes such as respiration or photosynthesis.

Phosphorylation is the process by which protons move through the ATP synthase releasing energy that causes the rotor and rod of the ATP synthase to rotate. The mechanical energy from this rotation is converted into chemical energy as phosphate is added to ADP to form ATP.

The release of one or two phosphate groups from ATP, a process called dephosphorylation, releases energy, i.e., the removal of a phosphate group from an organic compound changing ATP to ADP.

Respiration is the act  of respiring, which is the process by which a living organism or cell takes (inhales) oxygen from the air or water and exhales it. Photosynthesis is the process by which animals and plants use sunlight, water, and carbon dioxide to create oxygen and energy in the form of sugar.

This is exactly why today many health practitioners and coaches highly recommend people breathe properly to get proper oxygen intake and go out into the sun as often as possible.

The main purpose is to keep our cells oscillating/rotating in a clockwise manner with the clock of the earth (circadian rhythms) through environmental cues and managing bodily processes by consciously being aware and controlling them to a certain degree.

It is interesting to note that our microbiome creates and is in control of these natural rotations or oscillations in our gastrointestinal tracts. 

I contend that this rotation does not only occur within our GI tracts, but also around our bodies as a type of signaling molecule for these same said microbes.

Scientisists call this the “purine signaling pathway.”

A purine is an aromatic ring of atoms composed of carbon and nitrogen.  The main purinergic receptors are adenosine, ATP and UTP and purines include adenine and guanine, which participate in DNA and RNA formation

Purines are aromatic which means they have an aroma or smell.

This is why the human microbiome, comprising trillions of microorganisms residing in our gut, skin, and other body surfaces, plays a crucial role in not only maintaining our overall health and well-being, but also the way we smell and our bodily wastes smell.

This smell, I theorize, has a certain wavelength that signals or magnetizes these microorganisms to either live symbiotically within and around us or to command them to parasite/eat.

This is why when our ATP intake is low, fungal overgrowth will start to occur within our bodies.

This “purine signal” I theorize acts like a magnet or computer program that sends out wavelengths based on its energy production or lack thereof. Since fungi do not have eyes, ears and a nose, these wavelengths serve as biological commands in our environments for these microorganisms such as the fungi Candida and Aspergillus to either live mutually or symbiotically or for this relationship to become parasitic.

As within, so without and as without, so within.

According to a recent study:

The skin is colonized by a diverse microbiota. Many cutaneous organisms produce molecules that regulate colonization by other microorganisms and modify their intrinsic biology and behavior. The community of commensal species can act synergistically to alter local immune reactivity for mutual benefits of the commensals and the host without leading to pathology.

As part of a dynamic equilibrium between proinflammatory and immunoregulatory signals, extracellular adenosine (ADO) triphosphate (eATP) produced by commensal flora plays an important role in the regulation of immune detection, immune response, and ultimately a balance between host and commensal organisms such as Candida albicans (Mascanfroni et al., 2015).

The term “glia,” originating from the Greek word for “glue” because it is our glia cells that act as a type of super glue or more appropriately a carbon film like matrix that create an interface with oustide stimuli and organisms.

Glial cells play pivotal roles in the intricate functioning of the brain. Beyond their traditional perception as mere “glue” cells, glial cells play a crucial role in modulating the speed and efficiency of nerve signal transmission in maintaining the brain’s homeostasis and functionality.

One of the key functions of glial cells is their role in regulating the ionic environment surrounding nerve cells. By maintaining precise levels of ions such as potassium and calcium, glial cells create an optimal milieu for efficient signal propagation. This fine-tuned control helps ensure the rapid and accurate transmission of electrical impulses along neural circuits, ultimately contributing to the proper functioning of the brain.

Moreover, glial cells contribute significantly to the speed and efficiency of nerve signal transmission playing a crucial role in modulating synaptic activity by regulating the uptake of neurotransmitters. This function allows for precise control of neuronal communication, impacting various cognitive processes and behaviors.

Astrocytes, a prominent subtype of glial cells, play a crucial role in synaptogenesis and synaptic pruning, processes essential for refining neuronal connectivity and optimizing neural circuitry. By regulating neurotransmitter levels and providing metabolic support to neurons, astrocytes fine-tune synaptic transmission and facilitate efficient neuronal communication.

In 1994, researchers conducted experiments where they stimulated astrocytes in a dish, observing nearby neurons preparing to send signals in response. Building upon this, in 1997, Volterra and his team observed rat astrocytes responding to neurons with oscillating waves of the signaling molecule calcium.

Over the span of 2000 to 2012, more than 100 papers were published supporting the notion of astrocytes communicating via synapses.

While neurons are commonly depicted as trees with branching dendrites, astrocytes resemble a fungus, creating a dense network that covers the brain and facilitates information exchange among its components.

Neurofilament staining of human astrocytes

This intricate web of astrocytes appears to play a role in influencing neuronal activity. Further research unveiled fascinating insights into astrocytes’ impact on brain function.

For instance, in 2016, Kira Poskanzer’s work at the University of California, San Francisco revealed that mouse astrocytes can induce neighboring neurons into a rhythmic sleep state, highlighting the dynamic interplay between astrocytes and neurons in shaping brain activity.

According to UCLA:

Astrocytes have been implicated in a range of neurological and psychiatric disorders, including Alzheimer’s disease, Parkinson’s disease, epilepsy, stroke, traumatic brain injury and autism. Certain aspect of astrocyte function helps neural repair whereas astrocyte dysfunction exacerbates diseases. Scientists are only beginning to understand what roles astrocytes play in each type of brain disorder.”

Astrocytes are adept at controlling the concentration of ions in the extracellular space, which is essential for maintaining the resting membrane potential of neurons. By regulating the levels of ions, glial cells help in preventing excessive neuronal excitability or inhibition, thus contributing to the stability of neural signaling.

The discovery of astrocytes in 1865 marked a turning point, leading scientists to delve deeper into the world of glial cells and uncover a vast array of functions that go beyond mere structural support. From regulating the ionic environment surrounding nerve cells to influencing nerve signal transmission speed, controlling neurotransmitter uptake, and aiding in neural development through scaffold provision, glial cells have proven to be indispensable players in the neural orchestra.

This newfound understanding challenges the traditional notion of glial cells as passive bystanders and underscores their active and crucial involvement in brain physiology.

CONTROL YOUR GUT (MICROBIOME) OR IT WILL CONTROL YOU!

Our microbiome influences our digestion, metabolism, immune system, and even mental health. It aids in the breakdown of food, the synthesis of essential nutrients, and the protection against harmful pathogens.

These tiny inhabitants consist of bacteria, viruses, fungi, and other microorganisms that form a complex ecosystem within and AROUND us.

This intricate network of microbes communicates with our cells and influences gene expression, demonstrating its profound impact on our physiology.

This symbiotic and sometimes parasitic relationship between our microbiome and energy production pathways underscores the interconnectedness of our body’s systems and the profound impact it can have on our overall well-being.

Meaning exercise and movement, which causes our cells to respire and going the sun are important for this process to work correctly.

Regulation and Recycling of ATP in Living Organisms

Regulation and recycling of ATP in living organisms are vital processes that ensure the continuous availability of energy necessary for cellular activities. The intricate balance of ATP levels within cells is tightly regulated to meet the dynamic energy demands of various biological processes.

Cells possess sophisticated mechanisms to maintain optimal ATP levels. One crucial aspect of ATP regulation involves the enzymes responsible for ATP synthesis and degradation. ATP synthase, a key enzyme in cellular respiration, facilitates the production of ATP from adenosine diphosphate (ADP) and inorganic phosphate (Pi) during the process of oxidative phosphorylation.

Conversely, ATPases are enzymes that catalyze the hydrolysis of ATP to ADP and Pi, releasing energy that fuels cellular processes. ATP Hydrolysis is a chemical reaction where a phosphate bond that has been stored within ATP is broken by water after splitting these bonds, for example in muscles, by producing work in the form of mechanical energy.

When it comes to ATP production, understanding the differences between aerobic and anaerobic respiration pathways is crucial.

Aerobic respiration is the process that occurs in the presence of oxygen and is highly efficient, producing a large amount of ATP from glucose molecules. This process takes place in the mitochondria of cells and involves a series of complex reactions, including the citric acid cycle and oxidative phosphorylation.

On the other hand, anaerobic respiration occurs in the absence of oxygen and is less efficient compared to aerobic respiration. One common example of anaerobic respiration is fermentation, where glucose is partially broken down to produce ATP and byproducts such as lactic acid or ethanol fermentation. I

While anaerobic respiration can provide a quick burst of energy, it is not sustainable for long periods due to the accumulation of lactic acid which can lead to muscle fatigue.

ATP’s function is entirely reliant on the availability of ADP. Without an adequate supply, ATP synthase ceases to function correctly, causing it to dysfunction and decreased ATP production.

Meaning, at the cellular level, your cells start to stop spinning and producing energy.

In fact, it can start spinning counter clockwise.

This then rewires energy metabolism and causes enhanced glycolysis and inflammatory processes, which are a common feature of many age‐associated diseases, including Alzheimer’s, muscular dystrophy, ALS, diabetes and cancer.

This is called microbiota dysbiosis, which refers to an imbalance in the composition and function of the microbial communities that reside in our gut.

The meaning of the compound word dysbiosis is from the Greek dys which means bad and biosis, the way of life.

Dysbiosis has been linked to conditions such as irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), small intestinal bacterial overgrowth (SIBO), depression, anxiety, and autism spectrum disorders.

Intestinal epithelial cells (IECs) sense microbial stimuli through a number of different mechanisms that regulate IEC gene transcription and inflammatory responses.

It plays an important role in the digestion of food, absorption of nutrients, and protection of the human body from microbial infections, and others.

The intestinal epithelium is a highly dynamic tissue that provides both physical and chemical barriers to protect the intestinal mucosa and peripheral organs from commensal microbes or invading pathogenic microorganisms. In addition to forming a barrier, IECs also detect a myriad of signals from intestinal microbes, allowing fine tuning of IEC proliferation and homeostatic functions

It is the interface between us and them.

A deficiency in ATP synthase, believed to be triggered by mutations in the mtDNA genes for ATP subunits, contributes to various genetic mitochondrial diseases. Moreover, a range of conditions, including Alzheimer’s, muscular dystrophy, ALS, diabetes, and cancer, can induce secondary mitochondrial dysfunction.

Unfortunately, there are currently no known treatments for either secondary ATP deficiency or genetic mitochondrial diseases. However, researchers at the University of Colorado (CU) have been delving into the symbiotic relationship between gut bacteria and the human body, potentially uncovering a breakthrough for addressing ATP synthase deficiency.

They have devised a method to circumvent this limitation by leveraging fast-growing filamentous fungi, Neurospora crassa.

Neurospora crassa is a type of red bread mold of the genus of Ascomycete. The name, meaning ‘nerve spore’ in Greek, refers to resemblance to brain axons.

Neurospora research has found this fungi to be especially useful for studies of photobiology, circadian rhythms, population biology, morphogenesis, mitochondrial import, DNA repair and recombination, DNA methylation, and other epigenetic processes (Borkovich et al. 2004).

To be continued…

SOURCES:

Science Facts

Science Direct

Chemisty World

Colorado University

UCLA

University of Copenhagen

Univesity of Colorado